Searchable abstracts of presentations at key conferences in endocrinology

ea0011p286 | Diabetes, metabolism and cardiovascular | ECE2006

Gene variants at calpain-5 locus are associated with obesity and other features of metabolic syndrome

Saez ME , Martinez-Larrad MT , Ramirez-Lorca R , Gonzalez-Sanchez JL , Zabena C , Gonzalez A , Ruiz A , Serrano-Rios M

Introduction: Genes involved in common complex disorders such as obesity, type 2 diabetes mellitus (T2DM), dyslipidemia or hypertension are not disease specific, since clinically related disorders also share genetic components. These diseases cluster together in the Metabolic Syndrome, a generalized pathology with increased cardiovascular risk in which insulin resistance is considered a key feature. Cysteine protease Calpain-10 (CAPN10) has been associated with T2DM, polycysti...

ea0011p791 | Thyroid | ECE2006

Loss of heterozygosity and genetic association analyses within 11q13.5-q14 chromosomal region in papillary thyroid carcinoma

Ramirez-Lorca R , Ferrero Herrero E , Saez ME , Labalde Martinez M , Real LM , Ruiz A , Hidalgo Pascual M

Introduction: Papillary Thyroid cancer (PTC) accounts for 80% or more of all thyroid malignancies and genetic alterations associated with the development and progresion of this type of carcinoma remains largely unknown. Chromosomal band 11q13 seems to be one of the most frequently amplified regions in human cancer. Allelic imbalance involving EMSY, CAPN5 and PAK1 loci in thyroid cancer, have never been investigated. The aim of our study was to investigate the existence of alle...